Two silencing sub-domains of v-erbA synergize with each other, but not with RXR

Two silencing sub-domains of v-erbA synergize with each other, but not with RXR.

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is mediated by an active silencing mechanism rather then by interference with DNA binding activators. V-erbA, a variant form of TR which is unable to bind hormone, represents a constitutive repressor...

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site. In a tubulin assembly system containing microtubule-associated proteins and GTP, however, peloruside A was significantly less active than laulimalide, inducing assembly in a manner that was most similar to sarcodictyins A and B. Becau...

Dimerization Interfaces of V-erba Homodimers and Heterodimers with Rxrα

Association of v-ErbA with Smad4 Disrupts TGF- Signaling

Disruption of the transforming growth factor(TGF) pathway is observed in the majority of cancers. To further understand TGFpathway inactivation in cancer, we stably expressed the v-ErbA oncoprotein in TGFresponsive cells. v-ErbA participates in erythroleukemic transformation of cells induced by the avian erythroblastosis virus (AEV). Here we demonstrate that expression of v-ErbA was sufficient ...

construction of vector fields with positive lyapunov exponents

in this thesis our aim is to construct vector field in r3 for which the corresponding one-dimensional maps have certain discontinuities. two kinds of vector fields are considered, the first the lorenz vector field, and the second originally introced here. the latter have chaotic behavior and motivate a class of one-parameter families of maps which have positive lyapunov exponents for an open in...